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In reply to the discussion: White House touts Covid-19 'lab leak' theory on new website [View all]womanofthehills
(10,179 posts)Engineered bat virus stirs debate over risky research
Lab-made coronavirus related to SARS can infect human cells. https://www.nature.com/articles/nature.2015.18787
You need to be a working scientist to access this. Probably why Obama stopped gain of function research in US in 2014 - but Trump brought it back in 2019. Ralph Baric is Americas top coronavirus expert - his lab is bio level 3 at University of North Carolina. Shi is well known as the Bat Lady of Wujan.
Interesting article from MIT technology
In 2013, the American virologist Ralph Baric approached Zhengli Shi at a meeting. Baric was a top expert in coronaviruses, with hundreds of papers to his credit, and Shi, along with her team at the Wuhan Institute of Virology, had been discovering them by the fistful in bat caves. In one sample of bat guano, Shi had detected the genome of a new virus, called SHC014, that was one of the two closest relatives to the original SARS virus, but her team had not been able to culture it in the lab.
Baric had developed a way around that problema technique for reverse genetics in coronaviruses. Not only did it allow him to bring an actual virus to life from its genetic code, but he could mix and match parts of multiple viruses. He wanted to take the spike gene from SHC014 and move it into a genetic copy of the SARS virus he already had in his lab. The spike molecule is what lets a coronavirus open a cell and get inside it. The resulting chimera would demonstrate whether the spike of SHC014 would attach to human cells.
Really long but very interesting article Baric and Shi wrote papers together- -
https://www.technologyreview.com/2021/06/29/1027290/gain-of-function-risky-bat-virus-engineering-links-america-to-wuhan/
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